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FEBS Lett. 2012 Jul 4;586(14):1921-8. doi: 10.1016/j.febslet.2012.03.063. Epub 2012 Apr 9.

Dynamics of TGF-β/Smad signaling.

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BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg 79104, Germany.


The physiological responses to TGF-β stimulation are diverse and vary amongst different cell types and environmental conditions. Even though the principal molecular components of the canonical and the non-canonical TGF-β signaling pathways have been largely identified, the mechanism that underlies the well-established context dependent physiological responses remains a mystery. Understanding how the components of TGF-β signaling function as a system and how this system functions in the context of the global cellular regulatory network requires a more quantitative and systematic approach. Here, we review the recent progress in understanding TGF-β biology using integration of mathematical modeling and quantitative experimental analysis. These studies reveal many interesting dynamics of TGF-β signaling and how cells quantitatively decode variable doses of TGF-β stimulation.

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