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Curr Opin Virol. 2012 Aug;2(4):489-98. doi: 10.1016/j.coviro.2012.05.007. Epub 2012 Jun 17.

MCV and Merkel cell carcinoma: a molecular success story.

Author information

1
Molecular Virology program, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, United States.

Abstract

Merkel cell polyomavirus (MCV), discovered in 2008, is clonally integrated in ~80% Merkel cell carcinoma (MCC). MCV is a common skin flora and initiates cancer in susceptible hosts only after it acquires a precise set of mutations that render it replication incompetent. Both MCV large and small T proteins promote cancer cell survival and proliferation. Large T targets pocket proteins regulating cell cycle transit while small T activates cap-dependent translation critical for cancer cell growth. These findings already have led to new diagnostics and clinical trials to target MCV-induced survivin and to promote antitumor immunity. In four years, the cause, diagnosis and therapy for an intractable cancer has been changed due to the molecular discovery of MCV.

PMID:
22710026
PMCID:
PMC3422445
DOI:
10.1016/j.coviro.2012.05.007
[Indexed for MEDLINE]
Free PMC Article

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