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BMC Res Notes. 2012 Jun 15;5:299. doi: 10.1186/1756-0500-5-299.

Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes.

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  • 1Department of Biochemistry, Faculty of science, University of Dschang, P,O, Box 67, Dschang, Cameroon, Africa.

Abstract

BACKGROUND:

The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy.

RESULTS:

The extract of Cinnamomum zeylanicum against Escherichia coli ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of Dorstenia psilurus was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine-β- Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with erythromycin (ERY).

CONCLUSION:

The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.

PMID:
22709668
PMCID:
PMC3438083
DOI:
10.1186/1756-0500-5-299
[PubMed - indexed for MEDLINE]
Free PMC Article
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