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Curr Opin Virol. 2012 Jun;2(3):256-63. doi: 10.1016/j.coviro.2012.02.002. Epub 2012 Feb 28.

Pathogenesis of porcine reproductive and respiratory syndrome virus.

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Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS 66506, United States.


Porcine reproductive and respiratory syndrome virus (PRRSV) is the most costly viral pathogen facing a modern pig industry. A unique feature of the virus is the ability to cause severe clinical disease and maintain a life-long subclinical infection. Persistence at the population level poses the biggest challenge for the successful control and elimination of the disease. A mechanistic basis for persistence includes the evasion of innate and adaptive immune responses. Recent advances include the study of how the non-structural proteins (nsp's) inhibit the induction of type 1 interferon genes.

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