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Semin Dial. 2012 Sep-Oct;25(5):491-4. doi: 10.1111/j.1525-139X.2012.01090.x. Epub 2012 Jun 18.

N-acetylcysteine use for amelioration of aminoglycoside-induced ototoxicity in dialysis patients.


Use of aminoglycoside antibiotics is associated with significant ototoxicity, especially on patients with decreased renal function. The risk of aminoglycoside ototoxicity may approach 60%. Oxidative stress has been suggested as a general mechanism of aminoglycoside ototoxicity and is prevalent in dialysis population. N-acetylcysteine (NAC) is an effective antioxidant and has been safely used in dialysis patients. New experimental and clinical data, explored in this review, provide a good case to recommend NAC administration to all dialysis patients, receiving aminoglycosides.

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