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Psychiatry Investig. 2012 Jun;9(2):161-5. doi: 10.4306/pi.2012.9.2.161. Epub 2012 Apr 30.

Hippocampal neurochemical pathology in patients with panic disorder.

Author information

1
Department of Psychiatry, Firat University, School of Medicine, Elazig, Turkey. matmaca_p@yahoo.com

Abstract

OBJECTIVE:

In the present study, we measured hippocampal N-acetyl-l-aspartate (NAA), choline (CHO) and creatine (CRE) values in patients with panic disorder and healthy control subjects using in vivo(1)H MRS.

METHODS:

We scanned 20 patients meeting Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria for panic disorder and 20 matched healthy controls with a 1.5 Tesla GE Signa Imaging System and measured of NAA, CHO, and CRE in hippocampal regions.

RESULTS:

When NAA, CHO and CRE values were compared between groups, statistically significant lower levels for all ones were detected for both sides.

CONCLUSION:

Consequently, in the present study we found that NAA, CHO and CRE values of the patients with panic disorder were lower than those healthy controls. Future studies involving a large number of panic patients may shed further light on the generalizability of the current findings to persons with panic disorder.

KEYWORDS:

1H MRS; Choline; Creatine; N-acetylaspartate; Panic disorder

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