Send to

Choose Destination
Psychiatry Investig. 2012 Jun;9(2):161-5. doi: 10.4306/pi.2012.9.2.161. Epub 2012 Apr 30.

Hippocampal neurochemical pathology in patients with panic disorder.

Author information

Department of Psychiatry, Firat University, School of Medicine, Elazig, Turkey.



In the present study, we measured hippocampal N-acetyl-l-aspartate (NAA), choline (CHO) and creatine (CRE) values in patients with panic disorder and healthy control subjects using in vivo(1)H MRS.


We scanned 20 patients meeting Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) criteria for panic disorder and 20 matched healthy controls with a 1.5 Tesla GE Signa Imaging System and measured of NAA, CHO, and CRE in hippocampal regions.


When NAA, CHO and CRE values were compared between groups, statistically significant lower levels for all ones were detected for both sides.


Consequently, in the present study we found that NAA, CHO and CRE values of the patients with panic disorder were lower than those healthy controls. Future studies involving a large number of panic patients may shed further light on the generalizability of the current findings to persons with panic disorder.


1H MRS; Choline; Creatine; N-acetylaspartate; Panic disorder

Supplemental Content

Full text links

Icon for Publishing M2Community Icon for PubMed Central
Loading ...
Support Center