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Indian J Pharm Sci. 2011 Jul;73(4):447-51. doi: 10.4103/0250-474X.95648.

Phytochemical and antifungal profiles of the seeds of carica papaya L.

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Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062, India.


Phytochemical investigation of the ethanolic extracts of the seeds of Carica papaya L. (Caricaceae) led to the isolation of 2,3,4-trihydroxytoluene (caricaphenyl triol) and glyceryl-1-(2',3',4'-trihydroxybenzoyl)-2,3-dioleate (papayaglyceride) as the new phytoconstituents along with the known components glyceryl-1-oleiyl-2,3-dilinoleiate, glyceryl-1-oleiyl-2,3-diarachidate, glyceryl-1-linoleiyl-2,3-distearate, carpaine, glyceryl-1,2-dipalmitate, glyceryl trimyristate, glyceryl tristearate, glyceryl-1,2-dipalmityl-3-myristate, glyceryl-1-oleiyl-2,3-dimyristate, β-sitosterol glucoside, glyceryl-1-oleiyl-3-phosphate, glyceryl-1-oleiyl-2-lauryl-3-phosphate and glyceryl-1,2-distearyl-3-phosphate. The structures of all these compounds have been elucidated by spectral data analysis and chemical reactions. The methanolic extract of the seeds and 2,3,4-trihydroxytoluene (200 μg/ml) showed antifungal activity against Aspergillus flavus, Candida albicans and Penicillium citrinium.


2,3,4-trihydroxytoluene; 3-dioleate; Antifungal activity; Carica papya L.; glycerides; glyceryl-1-(2”3’4’-trihydroxybenzoyl)-2; seeds

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