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Mol Nutr Food Res. 2012 Jun;56(6):935-44. doi: 10.1002/mnfr.201200057.

Dietary rice bran component γ-oryzanol inhibits tumor growth in tumor-bearing mice.

Author information

1
Department of Molecular Science and Technology, Ajou University, Suwon, Republic of Korea.

Abstract

SCOPE:

We investigated the effects of rice bran and components on tumor growth in mice.

METHODS AND RESULTS:

Mice fed standard diets supplemented with rice bran, γ-oryzanol, Ricetrienol®, ferulic acid, or phytic acid for 2 weeks were inoculated with CT-26 colon cancer cells and fed the same diet for two additional weeks. Tumor mass was significantly lower in the γ-oryzanol and less so in the phytic acid group. Tumor inhibition was associated with the following biomarkers: increases in cytolytic activity of splenic natural killer (NK) cells; partial restoration of nitric oxide production and phagocytosis in peritoneal macrophages increases in released the pro-inflammatory cytokines tumor necrosis factor-α, IL-1β, and IL-6 from macrophages; and reductions in the number of blood vessels inside the tumor. Pro-angiogenic biomarkers vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), and 5-lipoxygenase-5 (5-LOX) were also significantly reduced in mRNA and protein expression by tumor genes. ELISA of tumor cells confirmed reduced expression of COX-2 and 5-LOX up to 30%. Reduced COX-2 and 5-LOX expression downregulated VEGF and inhibited neoangiogenesis inside the tumors.

CONCLUSION:

Induction of NK activity, activation of macrophages, and inhibition of angiogenesis seem to contribute to the inhibitory mechanism of tumor regression by γ-oryzanol.

PMID:
22707268
DOI:
10.1002/mnfr.201200057
[Indexed for MEDLINE]

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