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Ukr Biokhim Zh (1978). 1990 Sep-Oct;62(5):86-9.

[Activation of "silent" antibodies and their interaction with antigens].

[Article in Russian]

Abstract

Animal and human blood serum contains great amount of blocked (or "silent") immunoglobulins which, being activated by heating to 60 degrees C, pH decrease to 2.0-2.5 or treatment with 5M KSCN acquire a capacity to interact with different antigens. This interaction may be equally prevented or weakened by both identical and serologically non-related antigen, i.e. activated immunoglobulins are polyspecific. Polyspecific immunoglobulins show less affinity in comparison with monospecific antibodies, their interaction with antigens depends considerably on temperature.

PMID:
2270629
[Indexed for MEDLINE]

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