Format

Send to

Choose Destination
Hepat Mon. 2011 Apr 1;11(4):269-72.

Hepatitis D virus infection in Isfahan, central Iran: Prevalence and risk factors among chronic HBV infection cases.

Author information

1
Isfahan Infectious Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, IR Iran.

Abstract

BACKGROUND:

Hepatitis D virus (HDV) is dependent on hepatitis B virus (HBV) infection. Acute infection with HDV can occur simultaneously with acute HBV infection or be superimposed onto a chronic HBV infection.

OBJECTIVES:

This study aimed to identify cases of HDV and determine its prevalence in patients with chronic HBV infection for the first time study in Isfahan, central Iran.

PATIENTS AND METHODS:

In a cross-sectional study in 2009, 346 who had been diagnosed for at least 6 months with chronic HBV were enrolled consecutively. Anti-HDV was measured by ELISA in the serum of these patients.

RESULTS:

The study included 245 males (70.8%) and 101 (29.2%) females with a mean age of 39 ± 12.4 years. Anti-HDV was present in 8 (3.5%) HBe antibody-positive patients (p = 0.36) and in 2 (2.3%) HBe antigen-positive cases (p = 0.68). No association was found between hepatitis D and probable risk factors.

CONCLUSIONS:

This study demonstrates that the prevalence of HDV infection is higher in patients who are positive for HBeAb compared those who are HBeAg-positive. Therefore, most HDV antibody-positive cases in Isfahan are HBV/HDV superinfections but not coinfections.

KEYWORDS:

Hepatitis B infection; Hepatitis D infection; Iran; Prevalence

PMID:
22706272
PMCID:
PMC3206699

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center