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Eur J Cancer Prev. 2013 Jan;22(1):46-51. doi: 10.1097/CEJ.0b013e328355ed23.

Probiotics enhance the clearance of human papillomavirus-related cervical lesions: a prospective controlled pilot study.

Author information

1
Department of Primary and Interdisciplinary Care, Faculty of Medicine and Health Sciences, University of Antwerp, University Square 1, Wilrijk, Belgium. veronique.verhoeven@ua.ac.be

Abstract

Probiotics have been proposed for a number of urogenital infectious conditions. In this study, we examine a possible effect on human papillomavirus (HPV)-related precancerous lesions in cervical cytology. We conducted a prospective controlled pilot study, in which 54 women with an HPV+low-grade squamous intraepithelial lesion diagnosis in their PAP smear were followed for 6 months. The intervention group consumed a daily probiotic drink during the study period; the control group received no treatment, according to common care policy. Outcome measures were the control PAP smear and HPV status after 6 months. Probiotic users had a twice as high chance of clearance of cytological abnormalities (60 vs. 31%, P=0.05). HPV was cleared in 19% of control patients versus 29% of probiotic users (P=0.41). This exploratory pilot study suggests that the probiotic studied promotes the clearance of HPV-related cytological abnormalities. If confirmed, this would represent an entirely new option to manage cervical cancer precursors.

PMID:
22706167
DOI:
10.1097/CEJ.0b013e328355ed23
[Indexed for MEDLINE]

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