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Transfus Apher Sci. 2012 Dec;47(3):327-30. doi: 10.1016/j.transci.2012.04.006. Epub 2012 Jun 15.

Clinical factors influencing corrected count increment.

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Department of Transfusion Medicine in Kasturba, Medical College, Manipal University, Manipal, India.


Refractoriness to platelet transfusions is a common clinical problem. The present study was conducted to look into patient characteristics affecting the corrected count increment in a tertiary care referral hospital. A total of 161 aphaeresis platelet units were transfused to 40 patients with varied clinical diagnoses. The mean platelet increment was 17,789/mm(3). Median corrected count increment was 7344 and percentage platelet recovery was 22.82%. Logistic regression analysis revealed significant influence of splenomegaly and anti-platelet drugs on refractoriness. Fever, bleeding, sepsis, disseminated intravascular coagulation and cyclosporine use, though more common in the patients with refractoriness they were not statistically significant.

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