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Trends Plant Sci. 2012 Oct;17(10):584-93. doi: 10.1016/j.tplants.2012.05.004. Epub 2012 Jun 15.

The photomorphogenic repressors COP1 and DET1: 20 years later.

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Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8104, USA.


COP1 and DET1 are among the first repressors of photomorphogenesis to be identified, more than 20 years ago. Discovery of these repressors as conserved regulators of the ubiquitin-proteasome system has established protein degradation as a central theme in light signal transduction. COP1 is a RING E3 ubiquitin ligase that targets key regulators for degradation, and DET1 complexes with COP10 and DDB1, which is proposed to aid in COP1-mediated degradation. Recent studies have strengthened the role of COP1 as a major signaling center. DET1 is also emerging as a chromatin regulator in repressing gene expression. Here, we review current understanding on COP1 and DET1, with a focus on their role as part of two distinct, multimeric CUL4-based E3 ligases.

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