Format

Send to

Choose Destination
See comment in PubMed Commons below
Future Microbiol. 2012 Jun;7(6):719-31. doi: 10.2217/fmb.12.45.

Anaplasma phagocytophilum: deceptively simple or simply deceptive?

Author information

1
Department of Entomology & Center for Disease Vector Research, 900 University Avenue, University of California - Riverside, Riverside, CA 92521, USA.

Abstract

Anaplasma phagocytophilum is an obligate intracellular rickettsial pathogen transmitted by ixodid ticks. This bacterium colonizes myeloid and nonmyeloid cells and causes human granulocytic anaplasmosis--an important immunopathological vector-borne disease in the USA, Europe and Asia. Recent studies uncovered novel insights into the mechanisms of A. phagocytophilum pathogenesis and immunity. Here, we provide an overview of the underlying events by which the immune system responds to A. phagocytophilum infection, how this pathogen counteracts host immunity and the contribution of the tick vector for microbial transmission. We also discuss current scientific gaps in the knowledge of A. phagocytophilum biology for the purpose of exchanging research perspectives.

PMID:
22702526
PMCID:
PMC3397239
DOI:
10.2217/fmb.12.45
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon Icon for PubMed Central
    Loading ...
    Support Center