Format

Send to

Choose Destination
PLoS One. 2012;7(6):e38559. doi: 10.1371/journal.pone.0038559. Epub 2012 Jun 12.

Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients.

Author information

1
Molecular Oncology Group Investigation Center, Portuguese Institute of Oncology, Porto, Portugal. raquelcatarino@yahoo.com

Abstract

PURPOSE:

The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease.

METHODS:

We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology.

RESULTS:

We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations.

CONCLUSIONS:

Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.

PMID:
22701665
PMCID:
PMC3373551
DOI:
10.1371/journal.pone.0038559
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center