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Indian J Pharmacol. 2012 May;44(3):351-6. doi: 10.4103/0253-7613.96316.

Evaluation of protective effect of Aegle marmelos Corr. in an animal model of chronic fatigue syndrome.

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Department of Pharmacology, KLE University's College of Pharmacy, Rajajinagar, Bangalore, India.



To evaluate ethanolic extract of leaves of Aegle marmelos in an experimental animal model of chronic fatigue syndrome for potential therapeutic benefit.


Age/weight-matched female Wistar albino rats were grouped into five groups. (Group I- V) (n = 8). Group I served as naïve control and II served as stress control. Except for group I animals, other group animals were subjected to forced swimming every day for 15 minutes to induce a state of chronic fatigue and simultaneously treated with ethanolic extract of Aegle marmelos (EEAM) 150 and 250 mg/kg b.w. and Imipramine (20 b.w.), respectively. Duration of immobility, anxiety level and locomotor activity were assessed on day 1, 7, 14 and 21 followed by biochemical estimation of oxidative biomarkers at the end of the study.


Treatment with EEAM (150 and 250 mg/kg b.w.) resulted in a statistically significant and dose dependent reduction (P <0.001) in the duration of immobility, reduction in anxiety and increase in locomotor activity. Dose dependent and significant reduction in LPO level and increase in CAT and SOD was observed in extract treated animals.


The results are suggestive of potential protective effect of A. marmelos against experimentally induced CFS.


Aegle marmelos; chronic fatigue syndrome; duration of immobility; lipid peroxidation

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