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EMBO Rep. 2012 Aug;13(8):750-8. doi: 10.1038/embor.2012.88. Epub 2012 Jun 15.

Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling.

Author information

1
Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, #38 Xue Yuan Road, Beijing 100191, China.

Abstract

Kindlin 2, as a focal adhesion protein, controls integrin activation. However, the association of Kindlin 2 with cancer-related signalling pathways is unknown. Here we identified a new direct interaction between Kindlin 2 and the active β-catenin. Importantly, Kindlin 2 forms a tripartite complex with β-catenin and TCF4. Mechanistically, Kindlin 2 selectively strengthens the occupancy of β-catenin on the Wnt target gene Axin2 and enhances Axin2 gene expression. Functionally, the β-catenin-Axin2-Snail cascade is required for Kindlin 2-induced tumour cell invasion. Our data indicate that Kindlin 2 is a new regulator of Wnt signalling, providing a mechanistic insight into the role of Kindlin 2 in cancer progression.

PMID:
22699938
PMCID:
PMC3410388
DOI:
10.1038/embor.2012.88
[Indexed for MEDLINE]
Free PMC Article

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