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Hum Vaccin Immunother. 2012 Jun;8(6):823-7. doi: 10.4161/hv.20042. Epub 2012 Jun 1.

Hepatitis E vaccine development: a 14 year odyssey.

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National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Xiamen University, Xiamen, China.


The first prophylactic vaccine, HecolinĀ®, against hepatitis E virus (HEV) infection and the HEV associated disease was approved by China's State Food and Drug Administration (SFDA) in December 2011. Key milestones during the 14-year HEV vaccine development are summarized in this commentary.Ā  After years of innovative research the recombinant virus-like particle (VLP) based antigen with virion-like epitopes was successfully produced in E. coli production platform on a commercial scale. Safety and efficacy of this vaccine was demonstrated in a large scale phase III clinical trial.

[Indexed for MEDLINE]

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