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Lancet Neurol. 2012 Aug;11(8):720-31. doi: 10.1016/S1474-4422(12)70104-7. Epub 2012 Jun 13.

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets.

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1
Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA. rkeep@umich.edu

Abstract

Intracerebral haemorrhage accounts for about 10-15% of all strokes and is associated with high mortality and morbidity. No successful phase 3 clinical trials for this disorder have been completed. In the past 6 years, the number of preclinical and clinical studies focused on intracerebral haemorrhage has risen. Important advances have been made in animal models of this disorder and in our understanding of mechanisms underlying brain injury after haemorrhage. Several therapeutic targets have subsequently been identified that are now being pursued in clinical trials. Many clinical trials have been based on limited preclinical data, and guidelines to justify taking preclinical results to the clinic are needed.

PMID:
22698888
PMCID:
PMC3884550
DOI:
10.1016/S1474-4422(12)70104-7
[Indexed for MEDLINE]
Free PMC Article
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