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Dev Cell. 2012 Jun 12;22(6):1123-5. doi: 10.1016/j.devcel.2012.05.020.

Don't make me mad, Bub!

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Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.


The history of Bub1, a spindle checkpoint component, reveals a spectacular case of parallel evolution. In this issue of Developmental Cell, Suijkerbuijk et al. (2012) provide evidence that Bub1 has duplicated and diverged many times during eukaryotic evolution, dividing the functions of its ancestor between the two duplicated copies.

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