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Immunol Lett. 2012 Jul 30;145(1-2):55-61. doi: 10.1016/j.imlet.2012.04.011.

Dissection of inflammatory processes using chemokine biology: Lessons from clinical models.

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  • 1Medizinische Klinik und Poliklinik IV, Schillerstrasse 42, Ludwig-Maximilians-Universit√§t Munich, 80336 Munich, Germany. peter.nelson@med.uni-muenchen.de

Abstract

Chemokines help facilitate the recruitment of inflammatory cells into tissues in response to infection or inflammation, and help coordinate the actions of the leukocytes that underlie an immune response. Animal models are the experimental tools of choice for the validation of chemokine biology and have provided much insight into the workings of chemokine biology. This review summarizes findings from chemokine research obtained through the application of animal models of pulmonary fibrosis, graft-versus-host disease, colitis, renal disease and allograft rejection.

PMID:
22698184
DOI:
10.1016/j.imlet.2012.04.011
[PubMed - indexed for MEDLINE]
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