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Crit Rev Microbiol. 2013 Feb;39(1):79-101. doi: 10.3109/1040841X.2012.691460. Epub 2012 Jun 15.

Epidemiology and genetics of CTX-M extended-spectrum β-lactamases in Gram-negative bacteria.

Author information

1
Department of Microbiology and Immunology, Showa University School of Medicine, Tokyo, Japan. whzhao@med.showa-u.ac.jp

Abstract

CTX-M enzymes, the plasmid-mediated cefotaximases, constitute a rapidly growing family of extended-spectrum β-lactamases (ESBLs) with significant clinical impact. CTX-Ms are found in at least 26 bacterial species, particularly in Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis. At least 109 members in CTX-M family are identified and can be divided into seven clusters based on their phylogeny. CTX-M-15 and CTX-M-14 are the most dominant variants. Chromosome-encoded intrinsic cefotaximases in Kluyvera spp. are proposed to be the progenitors of CTX-Ms, while ISEcp1, ISCR1 and plasmid are closely associated with their mobilization and dissemination.

PMID:
22697133
PMCID:
PMC4086240
DOI:
10.3109/1040841X.2012.691460
[Indexed for MEDLINE]
Free PMC Article

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