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Angew Chem Int Ed Engl. 2012 Jul 16;51(29):7271-4. doi: 10.1002/anie.201203093. Epub 2012 Jun 13.

Concise total synthesis of (-)-myxalamide A.

Author information

1
Faculty of Pharmaceutical Sciences, Tokyo University of Science, 2641 Yamazaki, Noda-shi, Chiba 278-8510, Japan.

Abstract

The MIDA touch: A concise and highly convergent protecting-group-free total synthesis of (-)-myxalamide A involves a stereoselective vinylogous Mukaiyama aldol reaction of a vinylketene silyl N,O-acetal, together with a one-pot Stille/Suzuki-Miyaura cross-coupling reaction using Burke's N-methyliminodiacetic acid (MIDA) boronate to connect left- and right-hand fragments of the molecule (see scheme).

PMID:
22696208
DOI:
10.1002/anie.201203093
[Indexed for MEDLINE]

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