Characterization of two different toxins of Wickerhamomyces anomalus (Pichia anomala) VKM Y-159

Acta Biol Hung. 2012 Jun;63(2):277-87. doi: 10.1556/ABiol.63.2012.2.9.

Abstract

Wickerhamomyces anomalus VKM Y-159 strain produces two types of toxin designated as WAKT a and WAKT b, encoded by chromosomal genes. The WAKT a toxin is heat-labile, pronase sensitive acting in pH range 3-4 affecting on several yeasts including pathogenic Candida species while the WAKT b toxin is protease- and thermo-resistant, acting in pH range 3-7 on two species, Candida alai and Candida norvegica. The rapid decrease of the number of viable cells after toxin treatment demonstrates that both toxins have cytocidic effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Candida / drug effects
  • Cell Wall / chemistry
  • Killer Factors, Yeast / chemistry
  • Killer Factors, Yeast / toxicity*
  • Microbial Sensitivity Tests
  • Pichia / chemistry*
  • Polysaccharides / chemistry

Substances

  • Killer Factors, Yeast
  • Polysaccharides
  • WAKTa toxin, Pichia
  • WAKTb toxin, Pichia