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Cardiovasc Diabetol. 2012 Jun 13;11:67. doi: 10.1186/1475-2840-11-67.

Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning.

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1
Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South-1 West-16, Sapporo 060-8543, Japan. tmiki@sapmed.ac.jp

Abstract

In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial infarct size is a major determinant of prognosis in IHD patients, and development of a novel strategy to limit infarction is of great clinical importance. Ischemic preconditioning (PC), postconditioning (PostC) and their mimetic agents have been shown to reduce infarct size in experiments using healthy animals. However, a variety of pharmacological agents have failed to demonstrate infarct size limitation in clinical trials. One of the possible reasons for the discrepancy between the results of animal experiments and clinical trials is that co-morbidities, including DM, modified myocardial responses to ischemia/reperfusion and to cardioprotective agents. Here we summarize observations of the effects of DM on myocardial infarct size and ischemic PC and PostC and discuss perspectives for protection of DM hearts.

PMID:
22694800
PMCID:
PMC3461466
DOI:
10.1186/1475-2840-11-67
[Indexed for MEDLINE]
Free PMC Article
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