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J Nat Prod. 2012 Jun 22;75(6):1228-30. doi: 10.1021/np3002942. Epub 2012 Jun 13.

Lasionectrin, a naphthopyrone from a Lasionectria sp.

Author information

1
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avenida del Conocimiento 3, Parque Tecnológico de Ciencias de la Salud, E-18100 Armilla, Granada, Spain.

Abstract

A new naphthopyrone derivative, lasionectrin (1), was isolated from fermentations of an Acremonium-like fungus provisionally identified as a Lasionectria sp. (Ascomycota, Hypocreales) and isolated from forest leaf litter from Equatorial Guinea. Its structure was determined by a combination of spectroscopic techniques, including UV, (+)-HRESIMS, and 1D and 2D NMR spectroscopy, and comparison with published data for related fungal metabolites. Compound 1 inhibited the growth of Plasmodium falciparum with an IC(50) value of 11 μM.

PMID:
22694295
DOI:
10.1021/np3002942
[Indexed for MEDLINE]

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