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Org Lett. 2012 Jul 6;14(13):3237-9. doi: 10.1021/ol301240g. Epub 2012 Jun 13.

Efficient and highly aldehyde selective Wacker oxidation.

Author information

1
Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Abstract

A method for efficient and aldehyde-selective Wacker oxidation of aryl-substituted olefins using PdCl(2)(MeCN)(2), 1,4-benzoquinone, and t-BuOH in air is described. Up to a 96% yield of aldehyde can be obtained, and up to 99% selectivity can be achieved with styrene-related substrates.

PMID:
22694293
DOI:
10.1021/ol301240g
[Indexed for MEDLINE]

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