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Case Rep Med. 2012;2012:314056. doi: 10.1155/2012/314056. Epub 2012 May 27.

Hyperuricemic renal failure in nonhematologic solid tumors: a case report and review of the literature.

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Department of Internal Medicine, North Shore Medical Centre (NSMC), Salem, MA 01970, USA.


Tumor lysis syndrome (TLS) is an oncologic emergency that is caused by massive tumor cell lysis. It is commonly associated with hematological cancers like leukemia and lymphoma and uncommonly with solid nonhematologic tumors as well. However, spontaneous tumor lysis syndrome (STLS) without any cytotoxic chemotherapy rarely occurs in solid tumors. We describe a case of STLS in a metastatic adenocarcinoma of unknown primary and review the literature of STLS in solid non-hematologic tumors to identify various risk factors for pathogenesis of this entity.

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