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Transl Psychiatry. 2012 Jun 12;2:e127. doi: 10.1038/tp.2012.51.

Hippocampal subfields predict positive symptoms in schizophrenia: first evidence from brain morphometry.

Author information

1
Charité University Medicine, St Hedwig-Krankenhaus, Clinic for Psychiatry and Psychotherapy, Berlin, Germany. simone.kuhn@ugent.be

Abstract

Alterations of hippocampal anatomy have been reported consistently in schizophrenia. Within the present study, we used FreeSurfer to determine hippocampal subfield volumes in 21 schizophrenic patients. A negative correlation between PANSS-positive symptom score and bilateral hippocampal subfield CA2/3 as well as CA1 volume was found on high-resolution magnetic resonance images. Our observation opens the gate for advanced investigation of the commonly reported hippocampal abnormalities in schizophrenia in terms of specific subfields.

PMID:
22692142
PMCID:
PMC3384220
DOI:
10.1038/tp.2012.51
[Indexed for MEDLINE]
Free PMC Article
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