Format

Send to

Choose Destination
Autophagy. 2012 Jul 1;8(7):1009-31. doi: 10.4161/auto.19821. Epub 2012 Jun 13.

Emerging role of autophagy in kidney function, diseases and aging.

Author information

1
Renal Division, University Hospital Freiburg; Freiburg, Germany. tobias.huber@uniklinik-freiburg.de

Abstract

Autophagy is a highly conserved process that degrades cellular long-lived proteins and organelles. Accumulating evidence indicates that autophagy plays a critical role in kidney maintenance, diseases and aging. Ischemic, toxic, immunological, and oxidative insults can cause an induction of autophagy in renal epithelial cells modifying the course of various kidney diseases. This review summarizes recent insights on the role of autophagy in kidney physiology and diseases alluding to possible novel intervention strategies for treating specific kidney disorders by modifying autophagy.

KEYWORDS:

acute kidney injury; aging; autophagy; glomerulus; kidney; kidney transplantation; mTOR; podocyte; polycystic kidney disease

PMID:
22692002
PMCID:
PMC3429540
DOI:
10.4161/auto.19821
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center