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Oxid Med Cell Longev. 2012;2012:632959. doi: 10.1155/2012/632959. Epub 2012 May 28.

Polyphenols: key issues involved in chemoprevention of prostate cancer.

Author information

1
Department of Urology, University of Catania, 95125 Catania, Italy. ciminonello@hotmail.com

Abstract

Prostate cancer is is the most common solid neoplasm and it is now recognized as one of the most important medical problems facing the male population. Due to its long latency and its identifiable preneoplastic lesions, prostate cancer is an ideal target tumor for chemoprevention. Different compounds are available and certainly polyphenols represent those with efficacy against prostate cancer. This review take a look at activity and properties of major polyphenolic substances, such as epigallocatechin-3-gallate, curcumin, resveratrol and the flavonoids quercetin and genistein. Although the current studies are limited, mechanisms of action of polyphenols added with the lack of side effects show a a start for future strategies in prostate chemoprevention.

PMID:
22690272
PMCID:
PMC3368543
DOI:
10.1155/2012/632959
[Indexed for MEDLINE]
Free PMC Article

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