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Physiology (Bethesda). 2012 Jun;27(3):167-77. doi: 10.1152/physiol.00004.2012.

Striatal mechanisms underlying movement, reinforcement, and punishment.

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1
Gladstone Institute of Neurological Disease, University of California, San Francisco, California, USA.

Abstract

Direct and indirect pathway striatal neurons are known to exert opposing control over motor output. In this review, we discuss a hypothetical extension of this framework, in which direct pathway striatal neurons also mediate reinforcement and reward, and indirect pathway neurons mediate punishment and aversion.

PMID:
22689792
PMCID:
PMC3880226
DOI:
10.1152/physiol.00004.2012
[Indexed for MEDLINE]
Free PMC Article
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