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Int J Toxicol. 2012 Jul-Aug;31(4):326-36. doi: 10.1177/1091581812445185. Epub 2012 Jun 11.

Nonclinical toxicological evaluation of occidiofungin, a unique glycolipopeptide antifungal.

Author information

1
Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA.

Abstract

Occidiofungin, a glycolipopeptide obtained from the liquid culture of Burkholderia contaminans MS14, has been identified as a novel fungicide. The present study was designed to initially assess the in vitro toxicity in a rat hepatoma (H4IIE) cell line and acute toxicological effects of occidiofungin using a mouse model. In vitro toxicity was observed in all variables at 5 ╬╝mol/L. B6C3F1 mice were given single and repeat doses of occidiofungin up to 20 mg/kg. Key effects were a reduction in body and organ weights. However, no significant decrease in body weight was noted at a dose of 1 mg/kg, which is comparable to the dose level of other cyclic glycopeptide antifungal agents currently approved for human use. Microscopic examination of treated mice did not identify any signs of organ-specific toxicity at the dose levels tested.

PMID:
22689636
DOI:
10.1177/1091581812445185
[Indexed for MEDLINE]

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