Format

Send to

Choose Destination
See comment in PubMed Commons below
Angew Chem Int Ed Engl. 2012 Jul 9;51(28):7035-40. doi: 10.1002/anie.201201955. Epub 2012 Jun 11.

Activity-based probes for studying the activity of flavin-dependent oxidases and for the protein target profiling of monoamine oxidase inhibitors.

Author information

1
Institute of Organic Chemistry, Graz University of Technology, Austria.

Abstract

High profile: new activity-based protein profiling (ABPP) probes have been designed that target exclusively monoamine oxidases A and B within living cells (see picture; FAD=flavin adenine dinucleotide, FMN=flavin monodinucleotide). With these probes it could be shown that the MAO inhibitor deprenyl, which is in clinical use against Parkinson's disease, shows unique protein specificity despite its covalent mechanism of action.

PMID:
22689512
PMCID:
PMC3470703
DOI:
10.1002/anie.201201955
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center