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Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6908-11. doi: 10.1002/anie.201201690. Epub 2012 Jun 11.

Cyclic caged morpholinos: conformationally gated probes of embryonic gene function.

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  • 1Department of Chemical and Systems Biology, Stanford University School of Medicine, CA 94305, USA.

Abstract

Feeling a bit cagey: morpholino-based antisense reagents have been caged through oligonucleotide cyclization, enabling photocontrol of gene expression in zebrafish embryos and larvae. Using these reagents, the timing of exocrine cell fate commitment in the developing pancreas has been examined.

PMID:
22689470
PMCID:
PMC3434341
DOI:
10.1002/anie.201201690
[PubMed - indexed for MEDLINE]
Free PMC Article
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