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Gut Microbes. 2012 Jul-Aug;3(4):345-51. Epub 2012 Jun 12.

Understanding complex host-microbe interactions in Hydra.

Author information

1
Zoological Institute, Christian-Albrechts-Universität zu Kiel, Kiel, Germany. tbosch@zoologie.uni-kiel.de

Abstract

Any multicellular organism may be considered a metaorganism or holobiont-comprised of the macroscopic host and synergistic interdependence with bacteria, archaea, fungi, viruses, and numerous other microbial and eukaryotic species including algal symbionts. Defining the individual microbe-host conversations in these consortia is a challenging but necessary step on the path to understanding the function of the associations as a whole. Dissecting the fundamental principles that underlie all host-microbe interactions requires simple animal models with only a few specific bacterial species. Here I present Hydra as such a model with one of the simplest epithelia in the animal kingdom, with the availability of a fully sequenced genome and numerous genomic tools, and with few associated bacterial species.

PMID:
22688725
PMCID:
PMC3463492
DOI:
10.4161/gmic.20660
[Indexed for MEDLINE]
Free PMC Article

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