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Vox Sang. 2012 Nov;103(4):352-5. doi: 10.1111/j.1423-0410.2012.01620.x. Epub 2012 Jun 11.

Molecular characterization of a new D- - haplotype in a Comorian man.

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Établissement Français du Sang Alpes Méditerranée, Laboratoire d'Hématologie Moléculaire, UMR 7268, Aix-Marseille Université, France.


The D- - phenotype is a genetic variant of the Rh blood group system. It expresses D antigen but lacks C, c, E and e antigens. In D- - phenotype, the RHCE coding region is extensively modified by RHD sequence replacement, nucleotide deletion or splice-site changes. This article reports the identification of a new D- - haplotype in a Comorian man. It exhibits a hybrid gene in which RHCE gene exons 3-8 have been replaced by RHD sequences on the RHCE * C allele background. This allele is associated with no expression of c/C and e/E antigens and overexpression of RhD antigen.

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