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Org Lett. 2012 Jul 6;14(13):3256-9. doi: 10.1021/ol301078q. Epub 2012 Jun 11.

SelEXSIDE: fast and easy measurement of multiple-bond 1H,13C coupling constants for stereochemical analysis.

Author information

1
School of Chemistry, Cantocks Close, University of Bristol, Bristol, BS8 1TS, UK. Craig.Butts@bris.ac.uk

Abstract

Long-range (1)H,(13)C coupling constants ((n)J(CH)) are underutilized parameters for stereochemical structure determination, primarily because they are not easy to measure. This report describes a rapid and easily interpreted method for the measurement of one or more (n)J(CH) values based on a (13)C band-selective EXSIDE (SelEXSIDE), which reduces experiment times from many hours down to a few minutes while allowing a simple and straightforward readout of (n)J(CH) values from the resulting in-phase doublet signal.

PMID:
22686446
DOI:
10.1021/ol301078q

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