β-catenin inhibition synergizes with imatinib to delay CML recurrence

Cancer Discov. 2012 Jun;2(6):OF9. doi: 10.1158/2159-8290.CD-RW2012-050. Epub 2012 Apr 19.

Abstract

Genetic and pharmacologic inhibition of β-catenin blocks CML stem cell self-renewal.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Cyclooxygenase Inhibitors / pharmacology*
  • Drug Resistance, Neoplasm / drug effects*
  • Drug Resistance, Neoplasm / genetics*
  • Humans
  • Indomethacin / pharmacology*
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive*
  • Neoplastic Stem Cells / metabolism*
  • Piperazines / pharmacology*
  • Pyrimidines / pharmacology*
  • beta Catenin*

Substances

  • Antineoplastic Agents
  • Cyclooxygenase Inhibitors
  • Piperazines
  • Pyrimidines
  • beta Catenin
  • Indomethacin