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Brain Res. 2012 Jul 27;1467:42-7. doi: 10.1016/j.brainres.2012.05.051. Epub 2012 Jun 7.

Conditioned food aversion reconsolidation in snails is impaired by translation inhibitors but not by transcription inhibitors.

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1
Laboratory of Functional Neurochemistry, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Mokhovaya str. 11/4, 125009 Moscow, Russian Federation.

Abstract

Memory is destabilized during retrieval-induced reconsolidation and can therefore be disrupted or modified. In the present study, we examined the role of translation and transcription processes in long-term food aversion memory reconsolidation in the snail Helix lucorum. The administration of the protein synthesis inhibitor anisomycin followed by a reminding procedure (presentation of the conditioned stimulus) led to the development of amnesia that persist for 2 weeks or longer. Administration of the mRNA synthesis inhibitors actinomycin D, α-amanitin, or DRB (5,6-dichloro-1-β-D-ribofuranosylbenzimidasole) followed by a reminding procedure did not affect memory retrieval. Our present findings indicate that proteins synthesized from preexisting mRNA that is transcribed during learning and stored in a silent state may be involved in the mechanisms of conditioned food aversion reconsolidation.

PMID:
22683361
DOI:
10.1016/j.brainres.2012.05.051
[Indexed for MEDLINE]
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