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Biol Psychiatry. 2012 Oct 15;72(8):671-6. doi: 10.1016/j.biopsych.2012.05.008. Epub 2012 Jun 9.

Three dyslexia susceptibility genes, DYX1C1, DCDC2, and KIAA0319, affect temporo-parietal white matter structure.

Author information

1
Neuroscience Department, Karolinska Institutet, Stockholm, Sweden.

Abstract

BACKGROUND:

Volume and integrity of white matter correlate with reading ability, but the underlying factors contributing to this variability are unknown.

METHODS:

We investigated single nucleotide polymorphisms in three genes previously associated with dyslexia and implicated in neuronal migration (DYX1C1, DCDC2, KIAA0319) and white matter volume in a cohort of 76 children and young adults from the general population.

RESULTS:

We found that all three genes contained polymorphisms that were significantly associated with white matter volume in the left temporo-parietal region and that white matter volume influenced reading ability.

CONCLUSIONS:

The identified region contained white matter pathways connecting the middle temporal gyrus with the inferior parietal lobe. The finding links previous neuroimaging and genetic results and proposes a mechanism underlying variability in reading ability in both normal and impaired readers.

PMID:
22683091
DOI:
10.1016/j.biopsych.2012.05.008
[Indexed for MEDLINE]

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