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Fertil Steril. 2012 Sep;98(3):675-80. doi: 10.1016/j.fertnstert.2012.05.025. Epub 2012 Jun 7.

Idiopathic recurrent miscarriage is caused mostly by aneuploid embryos.

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1
NYU Fertility Center, New York, New York, USA.

Abstract

OBJECTIVE:

To determine any beneficial effects of preimplantation genetic screening (PGS) of all chromosomes by array comparative genomic hybridization (aCGH), with either day 3 or blastocyst biopsy, for idiopathic recurrent pregnancy loss (RPL) patients compared with their expected loss rate.

DESIGN:

Case series report.

SETTING:

Multiple fertility centers.

PATIENT(S):

A total of 287 cycles of couples with idiopathic RPL (defined as two or more losses).

INTERVENTION(S):

PGS was done with day 3 biopsy (n = 193) or blastocyst biopsy (n = 94), followed by analysis with aCGH.

MAIN OUTCOME MEASURE(S):

Spontaneous abortion rate, euploidy rate.

RESULT(S):

A total of 2,282 embryos were analyzed, of which 35% were euploid and 60% were aneuploid. There were 181 embryo transfer cycles, of which 100 (55%) became pregnant with an implantation rate of 45% (136 sacs/299 replaced embryos) and 94 pregnancies (92%) were ongoing (past second trimester) or delivered. The miscarriage rate was found to be only 6.9% (7/102), compared with the expected rate of 33.5% in an RPL control population and 23.7% in an infertile control population.

CONCLUSION(S):

Current PGS results with aCGH indicate a significant decrease in the miscarriage rate of idiopathic RPL patients and high pregnancy rates. Furthermore, this suggests that idiopathic recurrent miscarriage is mostly caused by chromosomal abnormalities in embryos.

[Indexed for MEDLINE]

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