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Fertil Steril. 2012 Aug;98(2):401-5. doi: 10.1016/j.fertnstert.2012.05.016. Epub 2012 Jun 7.

Association between appendicectomy in females and subsequent pregnancy rate: a cohort study.

Author information

1
Medicines Monitoring Unit, Division of Medical Sciences, School of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland.

Abstract

OBJECTIVE:

To study whether subsequent pregnancy rate is reduced after appendicectomy.

DESIGN:

A cohort study was carried out in the General Practice Research Database, a United Kingdom primary care database.

SETTING:

University hospital.

PATIENT(S):

Female patients who underwent appendicectomy between 1986 and 2009 and appropriate comparators were followed until first pregnancy.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

The association between appendicectomy and subsequent pregnancy was determined by Cox regression models.

RESULT(S):

The analyses included 76,426 appendicectomy patients, with 152,852 comparators from the database. There were 30,030 pregnancies (39.3%) in the appendicectomy cohort and 43,321 (28.3%) in the comparator cohort during a mean (SD) follow-up of 10.5 (6.6) years. Adjusted hazard ratios for subsequent birth rates were 1.54 (95% confidence interval, 1.52-1.56).

CONCLUSION(S):

Appendicectomy was associated with increased subsequent pregnancy rate in this study. This suggests that a history of appendicectomy is not associated with impaired fertility.

[Indexed for MEDLINE]

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