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J Stroke Cerebrovasc Dis. 2012 Nov;21(8):917.e1-4. doi: 10.1016/j.jstrokecerebrovasdis.2012.04.013. Epub 2012 Jun 8.

Cerebral venous sinus thrombosis: association with primary varicella zoster virus infection.

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Department of Neurology, Infectious Diseases, Medicine and Radiology, Aga Khan University, Karachi, Pakistan.


Varicella zoster virus (VZV) has been known to cause cerebral arterial vasculopathy and an acquired antibody-mediated coagulopathy associated with purpura fulminans and generalized thromboembolism. There are no published reports of cerebral venous sinus thrombosis (CVST) associated with primary VZV infection. We report 2 cases that highlight an unusual presentation of VZV infection: CVST with primary varicella infection. One patient had extensive CVST with coexistent middle cerebral artery involvement. Primary VZV infection can be associated with thrombosis of cerebral arteries and venous sinuses.

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