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Cell. 2012 Jun 8;149(6):1192-205. doi: 10.1016/j.cell.2012.05.012.

Wnt/β-catenin signaling and disease.

Author information

1
Hubrecht Institute, KNAW and University Medical Center Utrecht, The Netherlands. h.clevers@hubrecht.eu

Abstract

The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.

PMID:
22682243
DOI:
10.1016/j.cell.2012.05.012
[Indexed for MEDLINE]
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