Format

Send to

Choose Destination
Cell Metab. 2012 Jun 6;15(6):798-804. doi: 10.1016/j.cmet.2012.03.001.

Insulin resistance in the defense against obesity.

Author information

1
Life Sciences Institute, Departments of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA. saltiel@lsi.umich.edu

Abstract

In the face of the current obesity epidemic, the nature of the relationship between overnutrition and type 2 diabetes is of great importance. Obesity can be considered a state of excessive insulin action that elicits a series of cellular homeostatic responses, producing systemic insulin resistance. These responses occur in four steps: homologous desensitization to insulin action, leptin secretion, inflammation, and, finally, a counter-inflammatory phase that serves to conserve energy storage. The molecular mechanisms underlying these steps are discussed in the context of potential new therapeutic approaches.

PMID:
22682220
DOI:
10.1016/j.cmet.2012.03.001
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center