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Cell Metab. 2012 Jun 6;15(6):795-7. doi: 10.1016/j.cmet.2012.05.007.

Hidden variant of ChREBP in fat links lipogenesis to insulin sensitivity.

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1
Inserm U1016, Institut Cochin, 75014 Paris, France.

Abstract

The ChREBP transcription factor is regulated by glucose and plays a role in insulin sensitivity, but the mechanism underlying these effects remains unclear. In a recent Nature article, Herman et al. (2012) show that a shorter ChREBP isoform (ChREBP-β) links glucose transport to lipogenesis in white adipose tissue.

PMID:
22682219
DOI:
10.1016/j.cmet.2012.05.007
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