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Cell Metab. 2012 Jun 6;15(6):791-3. doi: 10.1016/j.cmet.2012.05.006.

REV-ERBs: more than the sum of the individual parts.

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1
Department of Molecular Biology, Sciences III, University of Geneva, 1211 Geneva, Switzerland.

Abstract

REV-ERB nuclear receptors have been believed to stabilize the circadian clock machinery through an accessory but dispensable feedback loop. Recent work now challenges this assumption by demonstrating that REV-ERBs are essential core clock components, in addition to serving as pivotal regulators of rhythmic metabolism.

PMID:
22682217
DOI:
10.1016/j.cmet.2012.05.006
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