Quantum phase slips are traditionally considered in diffusive superconducting wires which are assumed homogeneous. We present a definite estimate for the amplitude of phase slips that occur at a weak inhomogeneity in the wire where local resistivity is slightly increased. We model such a weak link as a general coherent conductor and show that the amplitude is dominated by the topological part of the action. We argue that such weak links occur naturally in apparently homogeneous wires and adjust the estimate to that case. The fabrication of an artificial weak link would localize phase slips and facilitate a better control of the phase-slip amplitude.