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Artif DNA PNA XNA. 2012 Jan-Mar;3(1):1-2. doi: 10.4161/adna.19672.

"Artifactual" arsenate DNA.

Author information

1
Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. ptrn@sund.ku.dk

Abstract

The recent claim by Wolfe-Simon et al. that the Halomonas bacterial strain GFAJ-1 when grown in arsenate-containing medium with limiting phosphate is able to substitute phosphate with arsenate in biomolecules including nucleic acids and in particular DNA(1) arose much skepticism, primarily due to the very limited chemical stability of arsenate esters (see ref. 2 and references therein). A major part of the criticisms was concerned with the insufficient (bio)chemical evidence in the Wolfe-Simon study for the actual chemical incorporation of arsenate in DNA (and/or RNA). Redfield et al. now present evidence that the identification of arsenate DNA was artifactual.

KEYWORDS:

DNA; arsenate; bacteria; genetic material; life

PMID:
22679526
PMCID:
PMC3368811
DOI:
10.4161/adna.19672
[Indexed for MEDLINE]
Free PMC Article
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